Presenter
Assoc. Prof. Kousuke Tsuchiya
Webbplats
https://www.u-tokyo.ac.jp/focus/en/people/k0001_05140.htmlWebinar: Kousuke Tsuchiya – Sustainable Functional Peptide-Based Materials Developed by Chemoenzymatic Synthesis
Welcome to the webinar by Assoc. Prof. Kousuke Tsuchiya from the University of Tokyo at Zoom or Rånby Room at KTH (Teknikringen 56)
This webinar is organised within the framework of the collaborative project between the KTH Department of Fibre and Polymer Technology (Dr. Antonio Capezza) and the University of Tokyo ( Sakai Laboratory ).
Project title: Joint Approach to Produce Porous Absorbent Natural Materials – J.A.P.A.N. Project
Abstract:
Chemoenzymatic polymerization of amino acid ester monomers catalyzed by proteases is a green and powerful method to synthesize functional polypeptides and peptide-based polyamides. The polymerization proceeds in aqueous media with only liberating small alcohol molecules as leaving groups, enabling the synthesis of peptide-based polyamides in an environmentally benign and atom-economical manner. Not only amino acid esters but also oligopeptide esters can be polymerized using proteases, which leads to polypeptides with a periodically repeated sequence. Using this method, we have synthesized several peptide motifs which play a key role to achieve the physical property as a target polypeptide. We have functionalized various polymeric applications depending on their sequences. For example, recent concerns about the environmental impact of polymer waste materials are motivating scientists to develop novel sustainable approaches to material production and material/chemical recycling. We synthesized a series of amino acid-based monomers containing an aromatic unit and polymerized them by protease-catalyzed polymerization to yield semi-aromatic polyamides containing peptide bonds in the main chain. The polyamides were able to be degraded by the treatment with proteases under specific conditions to recover the corresponding monomers in a high yield, indicating that the polyamides can be applied to protease-mediated chemical recycling for sustainable material cycles.
References [1] K. Tsuchiya and K. Numata, Macromol. Biosci., 2017, 17, 1700177. [2] K. Tsuchiya, K. Terada, T. Kurita, T. Watanabe, A. Lamprou, K. Numata, K, Biomacromolecues 2024, 25, 5110-5120. [3] K. Tsuchiya, H. Masunaga, K. Numata, ACS Sustainable Chem. Eng. 2025, 13, 3994-4004.
Biography:
Kousuke Tsuchiya, Associate Professor at the University of Tokyo Kousuke Tsuchiya received his Ph.D. degree in polymer chemistry from the Tokyo Institute of Technology in 2007 for the synthesis of functional polymers. He was appointed as an assistant professor at Tokyo University of Agriculture and Technology in 2007, and then he moved to Kinki University as assistant professor in 2012. In 2015, he began to conduct biochemical research regarding biopolymers including polypeptide materials at the RIKEN Center for Sustainable Resource Science. In 2020, he moved to Kyoto University as a program specific associate professor, and currently engaged to an associate professor at the University of Tokyo. He is also engaged in project research of JST PRESTO from 2021. His current work focuses on sustainable synthesis of biobased polymers including polypeptides. He was selected as Polymer Chemistry Emerging Investigators 2020 (RSC) for the research on the polypeptide-based materials.
Chemoenzymatic polymerization of amino acid ester monomers catalyzed by proteases is a green and powerful method to synthesize functional polypeptides and peptide-based polyamides. The polymerization proceeds in aqueous media with only liberating small alcohol molecules as leaving groups, enabling the synthesis of peptide-based polyamides in an environmentally benign and atom-economical manner. Not only amino acid esters but also oligopeptide esters can be polymerized using proteases, which leads to polypeptides with a periodically repeated sequence. Using this method, we have synthesized several peptide motifs which play a key role to achieve the physical property as a target polypeptide. We have functionalized various polymeric applications depending on their sequences. For example, recent concerns about the environmental impact of polymer waste materials are motivating scientists to develop novel sustainable approaches to material production and material/chemical recycling. We synthesized a series of amino acid-based monomers containing an aromatic unit and polymerized them by protease-catalyzed polymerization to yield semi-aromatic polyamides containing peptide bonds in the main chain. The polyamides were able to be degraded by the treatment with proteases under specific conditions to recover the corresponding monomers in a high yield, indicating that the polyamides can be applied to protease-mediated chemical recycling for sustainable material cycles.
References [1] K. Tsuchiya and K. Numata, Macromol. Biosci., 2017, 17, 1700177. [2] K. Tsuchiya, K. Terada, T. Kurita, T. Watanabe, A. Lamprou, K. Numata, K, Biomacromolecues 2024, 25, 5110-5120. [3] K. Tsuchiya, H. Masunaga, K. Numata, ACS Sustainable Chem. Eng. 2025, 13, 3994-4004.
Biography:
Kousuke Tsuchiya, Associate Professor at the University of Tokyo Kousuke Tsuchiya received his Ph.D. degree in polymer chemistry from the Tokyo Institute of Technology in 2007 for the synthesis of functional polymers. He was appointed as an assistant professor at Tokyo University of Agriculture and Technology in 2007, and then he moved to Kinki University as assistant professor in 2012. In 2015, he began to conduct biochemical research regarding biopolymers including polypeptide materials at the RIKEN Center for Sustainable Resource Science. In 2020, he moved to Kyoto University as a program specific associate professor, and currently engaged to an associate professor at the University of Tokyo. He is also engaged in project research of JST PRESTO from 2021. His current work focuses on sustainable synthesis of biobased polymers including polypeptides. He was selected as Polymer Chemistry Emerging Investigators 2020 (RSC) for the research on the polypeptide-based materials.
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